Table 1 Physicochemical characteristics of rosuvastatin niosomes
Run | A HLB of surfactant | B cholesterol concentration | C Drug content | Response 1 Mean vesicle size (nm) | Response 2 PDI (value) | Response 3 Zeta potential (mV) | Response 4 Entrapment Efficiency (%) |
|---|---|---|---|---|---|---|---|
F1 | 1 | -1 | 0 | 93.27 ± 9.43 | 0.27 ± 0.01 | -34.70 ± 720 | 68.12 ± 3.75 |
F2 | 0 | 0 | 0 | 168 ± 8.94 | 0.23 ± 0.05 | -37.47 ± 1.11 | 58.82 ± 1.63 |
F3 | -1 | 0 | -1 | 166.43 ± 7.28 | 0.23 ± 0.02 | -48.53 ± 2.50 | 21.39 ± 4.95 |
F4 | 1 | 1 | 0 | 148.53 ± 13.59 | 0.23 ± 0.00 | -26.23 ± 2.32 | 48.1 ± 5.8 |
F5 | 0 | 1 | -1 | 214.57 ± 13.02 | 0.28 ± 0.03 | -44.03 ± 5.92 | 28.3 ± 11.29 |
F6 | 0 | -1 | -1 | 145.47 ± 10.40 | 0.26 ± 0.08 | -46.03 ± 13.60 | 25.52 ± 17.15 |
F7 | 1 | 0 | 1 | 131.70 ± 3.39 | 0.28 ± 0.02 | -27.97 ± 0.23 | 65.58 ± 4.28 |
F8 | 0 | -1 | 1 | 164.57 ± 9.31 | 0.21 ± 0.00 | -30.27 ± 1.04 | 74.83 ± 1.88 |
F9 | -1 | 0 | 1 | 150.30 ± 19.11 | 0.27 ± 0.03 | -28.47 ± 0.50 | 67.32 ± 2.35 |
F10 | 0 | 0 | 0 | 164.23 ± 4.40 | 0.22 ± 0.03 | -43 ± 1.10 | 48.24 ± 2.43 |
F11 | -1 | -1 | 0 | 157.10 ± 7.16 | 0.23 ± 0.01 | -37.90 ± 1.78 | 59.72 ± 3.46 |
F12 | 1 | 0 | -1 | 117.47 ± 14.88 | 0.29 ± 0.01 | -35.43 ± 3.02 | 32.71 ± 7.08 |
F13 | 0 | 1 | 1 | 191.20 ± 7.97 | 0.34 ± 0.05 | -32.20 ± 2.00 | 70.67 ± 1.35 |
F14 | -1 | 1 | 0 | 214.33 ± 1.66 | 0.32 ± 0.02 | -30.40 ± 2.217 | 56.22 ± 2.68 |
F15 | 0 | 0 | 0 | 164.47 ± 2.39 | 0.22 ± 0.01 | -42.07 ± 2.27 | 60.77 ± 1.83 |