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  1. Ridge preservation is universally acknowledged as the conventional method for the post-extraction healing yet there are no standard materials for the ideal healing outcome. Herein, a composite gel comprising g...

    Authors: Shuai Yuan, Qingshu Li, Kaiwen Chen, Zhixiang Mu, Tao Chen, Huanan Wang and Ping Ji

    Citation: Journal of Biological Engineering 2021 15:19

    Content type: Research

    Published on:

  2. Since the advances in protein engineering and manufacture, over the last 30 years, antibody-based immunotherapeutic has become a powerful strategy to treat diseases. The T-cell engaging bispecific antibody (Bs...

    Authors: Lin Yu, Nan Huang, Liangpeng Ge, Heng Sun, Yuna Fu, Chundong Liu and Jianhua Wang

    Citation: Journal of Biological Engineering 2021 15:18

    Content type: Research

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  3. Skin wound healing is a complicated and lengthy process, which is influenced by multiple factors and need a suitable cellular micro-environment. For skin wound, wound dressings remain a cornerstone of dermatol...

    Authors: Chuan Fu, Zhiping Qi, Chengliang Zhao, Weijian Kong, Hongru Li, Wenlai Guo and Xiaoyu Yang

    Citation: Journal of Biological Engineering 2021 15:17

    Content type: Research

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  4. Many patients suffering from peripheral arterial disease (PAD) are dependent on bypass surgery. However, in some patients no suitable replacements (i.e. autologous or prosthetic bypass grafts) are available. A...

    Authors: Nicolai Seiffert, Peter Tang, Eriselda Keshi, Anja Reutzel-Selke, Simon Moosburner, Hannah Everwien, Dag Wulsten, Hendrik Napierala, Johann Pratschke, Igor M. Sauer, Karl H. Hillebrandt and Benjamin Struecker

    Citation: Journal of Biological Engineering 2021 15:15

    Content type: Research

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  5. A small scale stirred bioreactor was designed and the effect of different agitation rates (30, 60 and 100 rpm) was investigated on HepG2 cells cultured in alginate-chitosan (AC) core-shell microcapsule in term...

    Authors: Shahla Khodabakhshaghdam, Ali Baradar Khoshfetrat and Reza Rahbarghazi

    Citation: Journal of Biological Engineering 2021 15:14

    Content type: Research

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  6. Bioreactors are essential tools for the development of efficient and high-quality cell therapy products. However, their application is far from full potential, holding several challenges when reconciling the c...

    Authors: Oscar Fabian Garcia-Aponte, Christoph Herwig and Bence Kozma

    Citation: Journal of Biological Engineering 2021 15:13

    Content type: Review

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  7. The healing of large critical-sized bone defects remains a clinical challenge in modern orthopedic medicine. The current gold standard for treating critical-sized bone defects is autologous bone graft; however...

    Authors: Yonghyun Gwon, Sunho Park, Woochan Kim, Taeseong Han, Hyoseong Kim and Jangho Kim

    Citation: Journal of Biological Engineering 2021 15:12

    Content type: Research

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  8. Synthetic biological circuits are widely utilized to control microbial cell functions. Natural and synthetic riboswitches are attractive sensor modules for use in synthetic biology applications. However, tunin...

    Authors: Yunhee Hwang, Seong Gyeong Kim, Sungho Jang, Jongmin Kim and Gyoo Yeol Jung

    Citation: Journal of Biological Engineering 2021 15:11

    Content type: Research

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  9. In this review, we discuss violacein and prodigiosin, two chromogenic bacterial secondary metabolites that have diverse biological activities. Although both compounds were “discovered” more than seven decades ...

    Authors: Seong Yeol Choi, Sungbin Lim, Kyoung-hye Yoon, Jin I. Lee and Robert J. Mitchell

    Citation: Journal of Biological Engineering 2021 15:10

    Content type: Review

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  10. Short-chain fatty acids, especially butyrate, play beneficial roles in sustaining gastrointestinal health. However, due to limitations associated with direct consumption of butyrate, there has been interest in...

    Authors: Dah Hyun Jung, Ji Hyun Yong, Wontae Hwang, Mi Young Yoon and Sang Sun Yoon

    Citation: Journal of Biological Engineering 2021 15:9

    Content type: Research

    Published on:

  11. In this literature review, the antipathogenic properties and contact-mediated antibacterial and antiviral performance of copper cold spray surfaces are assessed and compared with alternative antimicrobial mate...

    Authors: Bryer C. Sousa, Christopher J. Massar, Matthew A. Gleason and Danielle L. Cote

    Citation: Journal of Biological Engineering 2021 15:8

    Content type: Review

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  12. Escherichia coli is a widely used platform for metabolic engineering due to its fast growth and well-established engineering techniques. However, there has been a demand for faster-growing E. coli for higher prod...

    Authors: Phuong N. L. VO, Hyang-Mi LEE, Jun REN and Dokyun NA

    Citation: Journal of Biological Engineering 2021 15:7

    Content type: Research

    Published on:

  13. The goal of the present study was to create a new biodegradable hybrid PCL-P (HEMA-NIPAAm) thermosensitive hydrogel scaffold by grafting PNIPAAm-based copolymers with biodegradable polyesters to promote the ch...

    Authors: Fereshteh Valipour, Farzaneh Valipour, Reza Rahbarghazi, Amir Mohammad Navali, Mohammad Reza Rashidi and Soodabeh Davaran

    Citation: Journal of Biological Engineering 2021 15:6

    Content type: Research

    Published on:

  14. Synthetic biomaterials assist in modulating the vascular response in an injured bone by serving as delivery vehicles of pro-angiogenic molecules to the site of injury or by serving as mimetic platforms which o...

    Authors: Wei He, Daixu Wei, Jun Zhang, Xiaonan Huang, Da He, Bo Liu, Qilong Wang, Mingming Liu, Ling Liu, Yajun Liu and Wei Tian

    Citation: Journal of Biological Engineering 2021 15:5

    Content type: Research

    Published on:

  15. Recognition proteins are critical in many biotechnology applications and would be even more useful if their binding could be regulated. The current gold standard for recognition molecules, antibodies, lacks co...

    Authors: Shivani Gupta Ludwig, Casey L. Kiyohara, Laura A. Carlucci, Dagmara Kisiela, Evgeni V. Sokurenko and Wendy Evelyn Thomas

    Citation: Journal of Biological Engineering 2021 15:3

    Content type: Research

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  16. In this study, we constructed recombinant luminescent Escherichia coli with T7, T3, and SP6 promoters inserted between tol and lux genes as toluene biosensors and evaluated their sensitivity, selectivity, and spe...

    Authors: Guey-Horng Wang, Teh-Hua Tsai, Chun-Chi Kui, Chiu-Yu Cheng, Tzu-Ling Huang and Ying-Chien Chung

    Citation: Journal of Biological Engineering 2021 15:2

    Content type: Research

    Published on:

  17. Bioactive ceramics are promising candidates as 3D porous substrates for bone repair in bone regenerative medicine. However, they are often inefficient in clinical applications due to mismatching mechanical pro...

    Authors: Yifan Li, Ronghuan Wu, Li Yu, Miaoda Shen, Xiaoquan Ding, Fengling Lu, Mengtao Liu, Xianyan Yang, Zhongru Gou and Sanzhong Xu

    Citation: Journal of Biological Engineering 2021 15:1

    Content type: Research

    Published on:

  18. The stem cells of human exfoliated deciduous teeth (SHEDs) are considered to be one of the main sources of seed cells in stem cell therapy. The aim of this study was to examine the effect of ciliary neurotroph...

    Authors: Sujuan Zeng, Xuedan Zhao, Lingling Zhang, Janak L. Pathak, Wenyan Huang, Yunyang Li, Hongbing Guan, Wanghong Zhao, Lihong Ge and Yan Shu

    Citation: Journal of Biological Engineering 2020 14:29

    Content type: Research

    Published on:

  19. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Yingying Xu, Hao Meng, Jie Ren and An-Ping Zeng

    Citation: Journal of Biological Engineering 2020 14:28

    Content type: Correction

    Published on:

    The original article was published in Journal of Biological Engineering 2020 14:15

  20. Hybrid fibrous mat containing cell interactive molecules offers the ability to deliver the cells and drugs in wound bed, which will help to achieve a high therapeutic treatment. In this study, a co-electrospun...

    Authors: Afshin Fathi, Mehdi Khanmohammadi, Arash Goodarzi, Lale Foroutani, Zahra Taherian Mobarakeh, Jamileh Saremi, Zohreh Arabpour and Jafar Ai

    Citation: Journal of Biological Engineering 2020 14:27

    Content type: Research

    Published on:

  21. Undergraduate biomedical engineering (BME) students interested in pursuing a career in research and development of medical or physiological monitoring devices require a strong foundation in biosignal analysis ...

    Authors: Karly S. Franz, Kramay Patel and Dawn M. Kilkenny

    Citation: Journal of Biological Engineering 2020 14:26

    Content type: Research

    Published on:

  22. Nerve guidance conduits (NGCs) have emerged from recent advances within tissue engineering as a promising alternative to autografts for peripheral nerve repair. NGCs are tubular structures with engineered biom...

    Authors: Caleb E. Stewart, Chin Fung Kelvin Kan, Brody R. Stewart, Henry W. Sanicola III, Jangwook P. Jung, Olawale A. R. Sulaiman and Dadong Wang

    Citation: Journal of Biological Engineering 2020 14:25

    Content type: Review

    Published on:

  23. Small-scale cultivation vessels, which allow fed-batch operation mode, become more and more important for fast and reliable early process development. Recently, the polymer-based feeding system was introduced ...

    Authors: Timm Keil, Barbara Dittrich, Clemens Lattermann and Jochen Büchs

    Citation: Journal of Biological Engineering 2020 14:24

    Content type: Research

    Published on:

  24. Current approach for diabetes treatment remained several adverse events varied from gastrointestinal to life-threatening symptoms. Regenerative therapy regarding Edmonton protocol has been facing serious limit...

    Authors: Suryo Kuncorojakti, Watchareewan Rodprasert, Supansa Yodmuang, Thanaphum Osathanon, Prasit Pavasant, Sayamon Srisuwatanasagul and Chenphop Sawangmake

    Citation: Journal of Biological Engineering 2020 14:23

    Content type: Research

    Published on:

  25. Traffic accidents, falls, and many other events may cause traumatic spinal cord injuries (SCIs), resulting in nerve cells and extracellular matrix loss in the spinal cord, along with blood loss, inflammation, ...

    Authors: Ziyuan Yu, Hongru Li, Peng Xia, Weijian Kong, Yuxin Chang, Chuan Fu, Kai Wang, Xiaoyu Yang and Zhiping Qi

    Citation: Journal of Biological Engineering 2020 14:22

    Content type: Review

    Published on:

  26. Whole-cell biosensors are a powerful and easy-to-use screening tool for the fast and sensitive detection of chemical compounds, such as antibiotics. β-Lactams still represent one of the most important antibiot...

    Authors: Nina Lautenschläger, Philipp F. Popp and Thorsten Mascher

    Citation: Journal of Biological Engineering 2020 14:21

    Content type: Research

    Published on:

  27. Mechanical stimuli play important roles on the growth, development, and behavior of tissue. A simple and novel paper-based in vitro tissue chip was developed that can deliver two types of mechanical stimuli—lo...

    Authors: Kattika Kaarj, Marianne Madias, Patarajarin Akarapipad, Soohee Cho and Jeong-Yeol Yoon

    Citation: Journal of Biological Engineering 2020 14:20

    Content type: Methodology

    Published on:

  28. Implantation failure remains an unsolved obstacle in reproductive medicine. Previous studies have indicated that estrogen responsiveness, specifically by estrogen receptor alpha (ERα), is crucial for proper im...

    Authors: Dganit Stern-Tal, Hanna Achache, Liora Jacobs Catane, Reuven Reich and Tali Tavor Re’em

    Citation: Journal of Biological Engineering 2020 14:18

    Content type: Research

    Published on:

  29. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Farhad Abasalizadeh, Sevil Vaghefi Moghaddam, Effat Alizadeh, Elahe Akbari, Elmira Kashani, Seyyed Mohammad Bagher Fazljou, Mohammadali Torbati and Abolfazl Akbarzadeh

    Citation: Journal of Biological Engineering 2020 14:17

    Content type: Correction

    Published on:

    The original article was published in Journal of Biological Engineering 2020 14:8

  30. Human mesenchymal stem cells (hMSCs) are intensely researched for applications in cell therapeutics due to their unique properties, however, intrinsic therapeutic properties of hMSCs could be enhanced by genet...

    Authors: Tyler Kozisek, Andrew Hamann, Albert Nguyen, Michael Miller, Sarah Plautz and Angela K. Pannier

    Citation: Journal of Biological Engineering 2020 14:16

    Content type: Research

    Published on:

  31. Glycine cleavage system (GCS) occupies a key position in one-carbon (C1) metabolic pathway and receives great attention for the use of C1 carbons like formate and CO2 via synthetic biology. In this work, we demon...

    Authors: Yingying Xu, Hao Meng, Jie Ren and An-Ping Zeng

    Citation: Journal of Biological Engineering 2020 14:15

    Content type: Research

    Published on:

    The Correction to this article has been published in Journal of Biological Engineering 2020 14:28

  32. The materials used in bone tissue engineering (BTE) have been advancing with each passing day. With the continuous development of nanomedicine, gold nanoparticles (GNPs), which are easy to be synthesized and f...

    Authors: Hongru Li, Su Pan, Peng Xia, Yuxin Chang, Chuan Fu, Weijian Kong, Ziyuan Yu, Kai Wang, Xiaoyu Yang and Zhiping Qi

    Citation: Journal of Biological Engineering 2020 14:14

    Content type: Review

    Published on:

  33. Choroidal neovascularization (CNV) is a major cause of blindness in patients with age-related macular degeneration. CNV is characterized by new blood vessel growth and subretinal fluid accumulation, which resu...

    Authors: Farhad Farjood, Amir Ahmadpour, Sassan Ostvar and Elizabeth Vargis

    Citation: Journal of Biological Engineering 2020 14:13

    Content type: Research

    Published on:

  34. Synthetic biology aims at engineering gene regulatory circuits to end with cells (re)programmed on purpose to implement novel functions or discover natural behaviors. However, one overlooked question is whethe...

    Authors: Roser Montagud-Martínez, Jordi Ventura, Rafael Ballesteros-Garrido, Arantxa Rosado and Guillermo Rodrigo

    Citation: Journal of Biological Engineering 2020 14:12

    Content type: Research

    Published on:

  35. Liver metabolites are used to diagnose disease and examine drugs in clinical pharmacokinetics. Therefore, development of an in vitro assay system that reproduces liver metabolite recovery would provide importa...

    Authors: Astia Rizki-Safitri, Marie Shinohara, Minoru Tanaka and Yasuyuki Sakai

    Citation: Journal of Biological Engineering 2020 14:11

    Content type: Research

    Published on:

  36. Low-magnitude mechanical stimulation (LMMS) may improve skeletal health. The objective of this research was to investigate the long-term residual effects of LMMS on bone health. 10-week old female mice were gi...

    Authors: Kyle A. Bodnyk, Kyle S. Kuchynsky, Megan Balgemann, Brooke Stephens and Richard T. Hart

    Citation: Journal of Biological Engineering 2020 14:9

    Content type: Research

    Published on:

  37. Hydrogels are a three-dimensional and crosslinked network of hydrophilic polymers. They can absorb a large amount of water or biological fluids, which leads to their swelling while maintaining their 3D structu...

    Authors: Farhad Abasalizadeh, Sevil Vaghefi Moghaddam, Effat Alizadeh, Elahe akbari, Elmira Kashani, Seyyed Mohammad Bagher Fazljou, Mohammadali Torbati and Abolfazl Akbarzadeh

    Citation: Journal of Biological Engineering 2020 14:8

    Content type: Review

    Published on:

    The Correction to this article has been published in Journal of Biological Engineering 2020 14:17

  38. In current cancer spheroid culturing methods, the transfer and histological processing of specimens grown in 96-well plates is a time consuming process. A centrifugal fluidic device was developed and tested fo...

    Authors: Warren Weisler, Samuel Miller, Shaphan Jernigan, Gregory Buckner and Matthew Bryant

    Citation: Journal of Biological Engineering 2020 14:7

    Content type: Research

    Published on:

  39. Demineralized bone matrix (DBM), an allograft bone processed to better expose osteoinductive factors such as bone morphogenetic proteins (BMPs), is increasingly used for clinical bone repair. However, more ext...

    Authors: Soyon Kim, Jiabing Fan, Chung-Sung Lee, Chen Chen, Ksenia Bubukina and Min Lee

    Citation: Journal of Biological Engineering 2020 14:6

    Content type: Research

    Published on:

  40. An efficient biodegradation-strengthening approach was developed to improve penicillin G degradation from industrial bacterial residue in an expanded bed adsorption bioreactor (EBAB) is reported in this paper.

    Authors: Peng Wang, Chen Shen, Xiaochun Wang, Shouxin Liu, Luwei Li and Jinfeng Guo

    Citation: Journal of Biological Engineering 2020 14:5

    Content type: Research

    Published on:

  41. Knowledge of glutamate excitotoxicity has increased substantially over the past few decades, with multiple proposed pathways involved in inflicting damage. We sought to develop a monosodium glutamate (MSG) exp...

    Authors: Rick Liao, Thomas R. Wood and Elizabeth Nance

    Citation: Journal of Biological Engineering 2020 14:3

    Content type: Research

    Published on:

  42. Aptamers, single-stranded DNAs or RNAs, can be selected from a library containing random sequences using a method called Systematic Evolution of Ligands by EXponential Enrichment (SELEX). In SELEX, monitoring ...

    Authors: Qingxiu Liu, Wei Zhang, Siying Chen, Zhenjing Zhuang, Yi Zhang, Lingli Jiang and Jun Sheng LIN

    Citation: Journal of Biological Engineering 2020 14:1

    Content type: Research

    Published on:

  43. Controlling of biofilms formation in numerous pathogenic bacteria is one of the most difficult tasks in the control of bacterial diseases. Plasma has attracted extensive attention due to their potential applic...

    Authors: Hyemi Seo, Jisoo Hong, Taeyeol Kim, Won ll Choi, Daekyung Sung and Eunpyo Moon

    Citation: Journal of Biological Engineering 2019 13:94

    Content type: Research

    Published on:

  44. This paper introduces a new technique combining microdialysis with patch clamp to detect the changes in ATP (adenosine triphosphate) concentration in acupoints during acupuncture. The microdialysis probe was i...

    Authors: Yong Wu, Meng Huang, Ying Xia and Guanghong Ding

    Citation: Journal of Biological Engineering 2019 13:93

    Content type: Research

    Published on: