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Fig. 5 | Journal of Biological Engineering

Fig. 5

From: Antler stem cell-derived exosomes promote regenerative wound healing via fibroblast-to-myofibroblast transition inhibition

Fig. 5

Effects of AnSC-exos on FMT in model rats. A Immunofluorescence stainings of α-SMA and TAGLN. B, C Numbers of α-SMA+ (except for blood vessel cells) and TAGLN+ cells on POD 14. D, E Relative mRNA levels of α-SMA and TAGLN on POD 14. F-H Western blot protein bands and relative intensities of α-SMA and TAGLN on POD 14. I, J Numbers of α-SMA+ (except for blood vessel cells) and TAGLN+ cells on POD 28. K, L Relative mRNA levels of α-SMA and TAGLN on POD 28. M-O Western blot protein bands and relative intensities of α-SMA and TAGLN on POD 28. Note: AnSC-exos down-regulated the expression levels of myofibroblast markers α-SMA and TAGLN, and this effect was comparable to that of AnSCs, but more potent than that of bMSC-exos. Mean ± SEM; *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001; n = 3. α-SMA, α-smooth muscle actin; TAGLN, transgelin

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