Dual-drug (Curcumin/Ciprofloxacin) loading and release from chitosan-based hydrogels embedded with magnetic Montmorillonite/Hyaluronic acid for enhancing wound healing

Table 2 The calculated kinetic parameters of Curcumin and Ciprofloxacin release according to Higuchi and Korsmeyer-Peppas models

		Higuchi model			Korsmeyer-Peppas model
		K_H	R²	n	K_KP	R²
For Curcumin loaded in hydrogel
Chito/HA	pH = 5.5	2.78	0.98	0.71	0.81	0.99
Chito/HA	pH = 7.4	1.9	0.97	0.89	014	0.98
Chito/HA-mMMt1	pH = 5.5	1.59	0.98	0.43	0.24	0.99
Chito/HA-mMMt1	pH = 7.4	7.68	0.95	0.45	042	0.98
Chito/HA-mMMt2	pH = 5.5	1.18	0.98	0.41	0.31	0.99
Chito/HA-mMMt2	pH = 7.4	1.73	0.95	0.37	0.24	0.99
For Ciprofloxacin loaded in hydrogel
Chito/HA	pH = 5.5	4.14	0.95	0.53	3.09	0.99
Chito/HA	pH = 7.4	4.28	0.99	0.46	7.03	0.98
Chito/HA-mMMt1	pH = 5.5	1.06	0.95	0.31	4.05	0.99
Chito/HA-mMMt1	pH = 7.4	1.98	0.95	0.28	8.16	0.98
Chito/HA-mMMt2	pH = 5.5	1.01	0.97	0.38	1.97	0.99
Chito/HA-mMMt2	pH = 7.4	1.68	0.96	0.44	2.32	0.98

ISSN: 1754-1611