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Fig. 12 | Journal of Biological Engineering

Fig. 12

From: Challenges of aortic valve tissue culture – maintenance of viability and extracellular matrix in the pulsatile dynamic microphysiological system

Fig. 12

α-SMA and CD31 immunohistochemistry staining of dynamic vs. statically cultured AV tissue sections: A Statically incubated pAV specimen after 14 days is shown (left, n = 3, representative sample shown); B Preliminary AV incubation setups under static conditions demonstrated increased focal α-SMA expression after 21 days; C CD31 epitopes of pAV tissue specimens are stained after 14 days of static incubation. The magnification shows neo-endothelial lining; D Quantification of CD31 expression (n = 3, scale bar: 200 µm; two-way-ANOVA; * p < 0.05)

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Journal of Biological Engineering

ISSN: 1754-1611