Table 6 Alteration of biological functions related to neurological disorders in MACO model

Aging

84

1.43E-09

TOP2A, CD86, NCF2, ELN, ITGB2, NPY2R, HP, HSPB1, ADM, LITAF, FGF2, CX3CL1, EDNRA, CASP7, CASP12, KRT25, LEPR, TSPO, TIMP1, GGT1, CTSC, SREBF1, NPY5R, IGFBP3, PRKCD, NGB, PLA2G4A, TACR3, GFRA1, NGF, TNFRSF1B, MMP9, F3, AGTR1A, ADRB3, DPYD, SERPING1, ALDOC, TP53, CRYAB, PPP1R15A, C1QB, CALCA, BCL2A1, CNP, SHC1, ADRB1, AURKB, PTGS1, CYP27B1, SOCS3, NPY, P2RY2, CCL2, DMD, MBP, APOE, BAK1, LDLR, TGFB2, JUN, VCAM1, TGFB1, ACE, NOS2, MOG, NOS3, VDR, TGFB3, STAT3, IGF1, CP, EPOR, AGT, NFKB2, FOSL2, IL6, COL3A1, KRT16, GJB6, KRT14, FAS, VIM, ADA

Response to axon injury

17

0.0059

LYN, PCSK1, GSTM1, MUSK, GIPR, NOS3, TXNRD1, LTC4S, FGF2, UCK2, LGALS1, NAIP6, DPYSL3, CDK1, TSPO, MATN4, MATN2

Stabilization of membrane potential

9

0.012

KCNK5, LOC100909725, KCNK6, KCNK10, KCNK13, KCNK15, KCNN4, KCNK1, KCNK4

Neuron differentiation

34

0.036

RET, BARHL2, CEBPB, WNT2B, SHC1, BHLHE22, RBPJ, HDAC9, NRBP2, WNT6, CASP3, S1PR1, WNT1, RXRG, HES5, HELT, WNT5B, EDN3, CNTN6, WNT7B, WNT9B, EN1, SOX11, TBR1, GFRA1, WNT9A, POU3F2, RUNX2, RUNX1, VGF, GDNF, LHX2, NES, HSPA1B

Myeloid dendritic cell differentiation

10

0.037

CD86, BATF3, SPI1, TGFB1, CAMK4, TNFSF9, LTBR, RBPJ, BATF, RELB

Mature conventional dendritic cell differentiation

5

0.039

F2RL1, PRTN3, CCR7, LGALS9, CCL19

Memory

23

0.042

IL1RN, CEBPB, OXTR, KCNK10, MUSK, NOG, IGF2, ADRB1, IGF1, NGF, PTGS2, SORCS3, KALRN, SLC6A4, PTGS1, SLC8A2, GRIN2A, JPH3, IL1B, ITGA5, FGF13, PLCB1, KCNK4

Negative regulation of neuron apoptotic process

35

0.022

REG3B, GABRB2, CEBPB, SCT, C5AR1, KIF14, FAIM2, GRIK2, HIF1A, HSPD1, NRBP2, CCL2, HMOX1, APOE, JAK2, NGFR, JUN, GABRA5, TGFB3, FZD9, EN1, MT1, NGF, MT3, EPOR, AGT, TOX3, NR4A3, GDNF, CLCF1, GFRAL, TYRO3, NES, TP73, LGMN