Table 5 Alteration of biological functions related to cell proliferation and apoptosis in MACO model

Positive regulation of cell proliferation

115

3.58E-09

CSF3, TNC, SCX, RBPJ, FGF1, LEXM, ETS1, FGF2, LGALS3, EDNRA, PLAU, MYC, ENPP2, PROK2, IL6R, CASR, SOX11, POU3F2, RUNX2, EREG, AR, PGR, IL6ST, ATF3, REG3B, SHC4, PTGFR, SHMT2, HIF1A, PLAC8, GHRHR, THPO, S100A13, WNT1, LOC501901, STAT5A, LYN, CBX8, WWTR1, TGFB2, JUN, TGFB1, TNFSF13, FN1, LIF, IL31RA, IGF1, CXCL10, IL6, CXCL12, GDNF, BAMBI, CDK2, FGF18, FGFR1, ITGB1, CDCA7L, FLT4, HTR2B, KIF14, LAMC2, ADM, YBX1, GLI1, ESM1, RAC2, TIMP1, JAK2, IL11, FGFBP1, EDN3, NPY5R, SPHK1, NOG, PLA2G4A, F2, OSMR, NGF, AGTR1A, HCK, CCKBR, RARA, HCLS1, GAS1, AVP, MFGE8, HBEGF, ODC1, DOT1L, NOD2, PTGS2, HLX, ERBB4, NPY, CXCR2, S1PR1, GCNT2, HAS2, HES5, TBX1, RRM2, WNT7B, STAT3, OSM, EPOR, AGT, KITLG, FABP4, PRC1, CLCF1, MAB21L2, RGD1565660, PTPN6, FOLR2

Regulation of cell proliferation

66

1.21E-08

ITK, CXCL6, CXCL9, B4GALT1, SERPINE1, TNC, CXCL1, CXCL3, DUSP15, RBPJ, TNF, CXCL2, PLAU, CHEK1, TEAD1, APOBEC1, ANXA1, IL4R, MATK, PLA2G4A, GKN2, TNFRSF1B, TNFRSF1A, FGR, HCK, IRF1, BIRC7, TNFRSF26, TP53, LAMA5, SHC1, PTGER2, TNFRSF11B, PTGS2, HIF1A, PTGS1, CNN2, CHST11, RELT, S100A11, TCFL5, TGFB2, TFAP2C, TGFB1, JUP, NOS2, PTCH1, TNFRSF10B, CELA1, PRG4, IGF1, FA2H, CXCL10, IL6, CXCL11, BCL6, FES, TNFSF9, FAS, CD27, LTBR, MELTF, LGR5, MYD88, PLCD1, FGFR1

Positive regulation of apoptotic process

77

5.54E-06

TOP2A, ITGB1, B4GALT1, ADM, TNF, PTPRF, PYCARD, CASP8, CASP12, CASP3, TNFSF10, TSPO, CYP1B1, JAK2, PHLDA1, TGM2, ANXA1, TNFRSF12A, IGFBP3, PRKCD, PAWR, PLA2G4A, ANO6, NGF, MMP9, ALDH1A3, PLSCR1, MELK, SHQ1, FOLH1, GAL, IL1B, ALDH1A1, PPARG, TP53, GPLD1, PPP1R15A, BCL2A1, ADRB1, PTGS2, HIF1A, HSPD1, NEUROD1, LDHA, GRIN2A, C6, MUC2, ERBB4, HMOX1, PMAIP1, RIPK1, BAK1, SLIT2, MAP2K6, NGFR, TGFB2, JUN, TGFB1, ACE, NOS2, GADD45B, NOS3, GADD45A, TGFB3, OSGIN1, GADD45G, NFATC4, FOSL1, ADCY10, NELL1, REST, IL6, BCL6, FAS, MNDA, PDCD1, TP73

Organ regeneration

32

5.54E-06

CXCL6, CDKN1A, NNMT, SHC1, FLT3, C5AR1, HP, HMGB2, HTR2C, ADM, SOCS3, SOCS1, FPGS, CCL2, BAK1, UGT1A2, WNT1, ANGPT2, TGFB1, ACE, ANXA3, LIF, APOA5, HSPG2, F7, CXCL12, NR4A3, CDK2, CDK1, PPARG, ALDOC, LCP1

Positive regulation of smooth muscle cell proliferation

28

8.68E-05

SHC1, ITGB3, PTGS2, RBPJ, TNF, FGF2, HIF1A, CX3CL1, MYC, PDGFD, S1PR1, C3AR1, HMOX1, IL6R, HES5, TGM2, JUN, NPY5R, ITGA2, CYBA, IRAK4, IGF1, SULF1, EREG, IL6, NR4A3, MYD88, HBEGF

Negative regulation of cell proliferation

78

1.26E-04

ITGB1, IFITM3, CDKN1A, B4GALT1, TES, FLT3, ADM, RBPJ, TNF, FGF2, PTPRF, RXFP2, NPPC, GJA1, BDKRB2, WDR6, CYP1B1, JAK2, SOX7, TGIF1, IGFBP3, ITGA1, P3H2, WNT9A, ETV3, HSPG2, EREG, RUNX1, AR, GAL, IL1B, IRF1, RARA, PPARG, TAX1BP3, TP53, GPLD1, PTGES, PPP1R15A, SLFN2, TWIST2, PTGS2, DLL4, CYP27B1, MUC2, ERBB4, XIRP1, HMOX1, BAK1, SLIT2, LYN, BCHE, SMAD1, TGFB2, JUN, TGFB1, NOS3, VDR, TGFB3, PTCH1, STAT3, LIF, HMGA1, OSM, FUZ, INHBA, IGF1, SMARCA2, AGT, FOSL1, REST, IL6, BCL6, CTH, GJB6, CD9, PTPN2, TP73

Positive regulation of fibroblast proliferation

23

0.0012

TGIF1, NGFR, CDKN1A, JUN, TGFB1, ANXA2, SPHK1, ITGB3, SERPINE1, FNDC3B, FN1, IGF1, ESR1, KNG2, KNG1, AGT, FOSL2, AQP1, EREG, ZMIZ1, MYC, PDGFD, WNT1

Brown fat cell differentiation

15

0.0014

CEBPB, LAMB3, EBF2, ADRB1, PTGS2, PLAC8, SELENBP1, RGS2, ALDH6A1, FABP4, LRG1, ADRB3, MB, PPARG, SH2B2

Endodermal cell differentiation

13

0.0030

LAMB3, ITGB2, LAMA3, FN1, INHBA, MMP8, MMP9, VTN, MMP14, MMP15, COL7A1, COL8A1, ITGA5

Apoptotic process

71

0.0030

CLIC4, NCF1, BUB1B, FAIM2, ECE1, HIF3A, AHR, TNF, LITAF, PYCARD, CASP7, GJA1, CASP8, LGALS1, CASP12, PPP1R13L, CASP3, ZC3H12A, CASP4, PIM1, TRIM69, MAP3K8, PHLDA1, LGALS7, CTSC, CASR, DCC, PRKCD, PAWR, DIO3, TOX3, PLSCR1, MELK, CCKBR, IRF1, CHI3L1, ALDOC, AVP, DNASE1, TP53, S100A9, S100A8, BIRC3, SHC4, PPP1R15A, ASAH2, BCL2A1, SEMA3A, C5AR1, SLC5A11, ADRB1, NUAK2, MUC2, CCL6, PMAIP1, RIPK1, BAK1, MAP2K6, SIAH3, RHBDD1, NEK6, CFLAR, MT3, CIDEC, GADD45G, GZMM, GJB6, CDK1, FAS, FGF13, XAF1

Negative regulation of apoptotic process

91

0.0083

CDKN1A, IL1RN, FLT4, HHIP, HTR2B, KIF14, SCX, HSPB1, SLC2A3, YBX1, RXFP2, AQP1, LGALS3, EDNRA, CASP3, CLEC5A, PIM1, PROK2, SOX8, TIMP1, JAK2, IER3, SERPINB2, NPY5R, SPHK1, PLAUR, NGF, MMP9, TNFRSF1A, ADAMTS20, HCK, RARA, GAS1, PGR, BIRC7, AVP, ANGPTL4, TP53, CARD14, CRYAB, STK40, CD44, BIRC3, REG3B, PTGFR, LTK, BCL2A1, TWIST2, THY1, THBS1, HIF1A, HSPD1, PLAC8, SOCS3, NUAK2, CHST11, IRAK2, CBS, ERBB4, FIGNL1, CXCR2, FLNA, LOC501901, STAT5A, NGFR, TGFB2, JUN, RHBDD1, STAT3, FN1, CFLAR, IGF1, MT3, KITLG, IL6, NR4A3, LHX3, BCL6, CTH, IL2RB, BCL3, ALB, CDK1, FAS, CD27, RGD1565660, PDCD1, MYD88, ADA, HSPA1B, LIMS1

Apoptotic signaling pathway

17

0.025

NGFR, CD40, PTGIS, VDR, PAWR, TNFRSF11B, TICAM1, NGF, TNFRSF1B, TNF, CASP8, CD28, FAS, LTBR, TNFRSF26, BAK1, RELT