Table 4 Alteration of biological functions related to immune and inflammatory responses in MACO model

Inflammatory response

106

6.03E-23

NCF1, TRIL, TNF, NPPB, PYCARD, ZC3H12A, C3AR1, LGALS9, MAP2K3, IL4R, SLC11A1, CYBB, CYBA, NAIP6, CD8A, S100A8, PTGFR, CALCA, C5AR2, C5AR1, TNFRSF11B, MEFV, KNG2, KNG1, C3, IRAK2, NLRP3, CD14, CCR1, NGFR, SMAD1, TGFB1, TNFRSF10B, CELA1, SERPINA3N, SELE, NFKB2, SELP, CXCL10, CXCL11, IL6, CXCL12, REL, CD27, SDC1, MYD88, TP73, CXCL6, CD40, ECM1, CXCL9, SERPINA1, CXCL1, CXCL3, CXCL2, CX3CL1, CASP4, NFKBIZ, OLR1, CCR7, PTGIR, ANXA1, SPHK1, TNFRSF1B, NGF, AGTR1A, TNFRSF1A, HCK, GAL, IL1B, CHI3L1, TLR10, TNFRSF26, CD44, TLR13, CCL12, PTGER2, PTGER3, PTGS2, THBS1, PTGS1, RELB, CCL9, CCL7, CNR2, DDT, CCL6, PDPN, CCL4, SPP1, CCL3, CCL2, S1PR3, CCL19, RELT, KCNJ10, CCL22, NOS2, CCL20, KRT16, CAMK4, PLP1, FAS, F2RL1, ACKR2, LTBR

Neutrophil chemotaxis

33

4.09E-12

CCL12, CSF3R, ITGAM, C5AR1, ITGB2, CXCL1, TREM3, CXCL3, TREM1, CXCL2, CX3CL1, LGALS3, CCL9, CCL7, CCL6, CXCR2, CCL4, CCL3, SPP1, PDE4B, CCL2, CCL19, TGFB2, FCER1G, CCL22, EDN3, CCL20, ITGA1, VAV1, FCGR2A, IL1B, S100A9, S100A8

Immune response

74

3.42E-09

CXCL6, CSF3, CXCL9, EDA, LST1, CXCL1, CXCL3, TNF, CXCL2, CX3CL1, FCAR, TNFSF13B, VPREB3, ENDOU, ENPP2, TNFSF10, CCR7, CD36, ENPP3, SECTM1B, SBSPON, IL4R, RT1-CE4, RT1-CE5, TNFRSF1B, LAX1, RT1-CE3, VAV1, TNFRSF1A, ZAP70, PLSCR1, SLPI, IL1B, IRF8, TNFRSF26, RT1-CE10, C1QB, CD274, LOC103690020, CXCR5, OAS1A, RT1-A1, TNFRSF11B, RT1-A2, THBS1, OAS1F, VTN, C6, NFIL3, CCL4, RELT, CCR1, NGFR, CCL22, RT1-DMB, ZFR2, TNFSF15, TNFSF13, LIF, OSM, TNFRSF10B, PRG4, CXCL10, CXCL11, CXCL12, CD28, TNFSF9, FAS, CD27, TNFSF8, LTBR, FCGR2B, CD244, RT1-T24-4

Cellular response to interleukin-1

39

5.65E-09

CCL12, CD40, CEBPB, PTGER3, SERPINE1, HIF1A, CXCL2, CX3CL1, ICAM1, PYCARD, CCL9, CCL7, CCL6, MYC, P2RY2, CCL4, ZC3H12A, CCL3, CCL2, HAS2, APOE, CCL19, ADAMTS7, CCL22, PTGIS, NOS2, CCL20, MMP3, FN1, PAWR, ACOD1, SERPINA3N, MMP9, PSMB9, IL6, IRF1, LCN2, FAS, CHI3L1

Positive regulation of inflammatory response

29

3.37E-08

CCL12, SERPINE1, TNF, ETS1, CX3CL1, HSPD1, CCL9, EDNRA, CCL7, CCL6, CCL4, CCL3, CCL2, JAK2, LDLR, TGM2, STAT5A, TNFSF18, ACE, ITGA2, PLA2G4A, IL17RB, TNFRSF1A, GPRC5B, FABP4, TRPV4, TLR10, S100A9, S100A8

Cytokine-mediated signaling pathway

46

3.37E-08

RTN4R, LRRC15, IL1RN, CSF3R, FLT3, LRRC4, IL20RB, CSF2RB, IL2RG, CX3CL1, SOCS3, DUOX1, IL1RL2, SOCS1, LRRTM3, LRRTM1, CCL2, JAK2, JAK3, IL6R, DUOX2, SH2B2, SOCS4, STAT5A, IL4R, CISH, IL10RB, IL1R1, IL1R2, BGN, IFNLR1, IRAK4, OSMR, F3, IL17RC, IL17RB, TNFRSF1A, EREG, KLF6, IL6, IL1B, IL2RB, IL7R, IL6ST, MYD88, CD44

Response to cytokine

36

3.07E-07

CD274, OXTR, SERPINA1, SERPINE1, PTGS2, CXCL16, RELB, SOCS3, SOCS1, ACP5, TIMP1, SKIL, IL6R, TIMP4, JUN, TGFB2, NOS3, STAT3, MMP3, SERPINA3N, OSMR, SELE, NFKB2, FOSL2, FOSL1, GH1, COL3A1, IL6, MAPKAPK3, RARA, REL, FAS, IL6ST, TP53, CFTR, PTGES

Leukocyte cell–cell adhesion

16

3.10E-06

ITGB1, CALCA, VCAM1, ITGAM, ITGB2, MSN, ITGAL, SELE, ICAM1, SELP, NT5E, PTPRC, OLR1, ITGA5, EZR, FERMT3

Chemokine-mediated signaling pathway

24

8.61E-06

CCR1, CXCL6, CXCL9, CCL12, CCL22, CCL20, CXCR5, CXCR4, CXCL1, CXCL3, CXCL2, CX3CL1, CXCL10, CCL9, CXCL11, CXCL12, CCL7, CCL6, CXCR2, CCL4, CCL3, CCL2, ACKR2, CCL19

Chemotaxis

25

2.01E-05

CXCL9, C5AR2, C5AR1, HMGB2, CXCR5, CXCR4, LSP1, CX3CL1, AMOT, C3, CXCR2, CCL3, ENPP2, S1PR1, C3AR1, RAC2, PROK2, CCR7, CMKLR1, LYN, CCL20, CXCL10, CXCL11, FES, ACKR2

Acute-phase response

18

6.83E-05

REG3B, REG3A, IL1RN, SERPINA1, STAT3, HP, FN1, REG3G, F2, HIF1A, KNG1, SIGIRR, PLSCR1, IL6, TFR2, LBP, A2M, LOC100911545

Leukocyte migration

17

9.63E-05

B4GALT1, C5AR2, C5AR1, MSN, TNF, SELE, MMP9, ICAM1, SELP, SELL, PODXL, IL1B, C3AR1, PDE4B, F2RL1, ITGB7, CD34

Positive regulation of neutrophil chemotaxis

14

1.53E-04

C5AR1, CXCL1, CXCL3, CXCL2, THBS4, EDNRA, SELL, IL1B, CXCR2, C3AR1, RAC2, CCR7, CCL19, LBP

Cellular response to interferon-gamma

22

4.39E-04

CCL12, CCL22, NOS2, CCL20, ACOD1, SERPINA3N, EPRS, CX3CL1, ICAM1, CCL9, ADAMTS13, CCL7, CCL6, MYC, CCL4, CCL3, CCL2, LGALS9, CCL19, LOC685067, GBP2, GBP1

Cellular response to cytokine stimulus

18

5.96E-04

STAT5A, CD86, CSF3, MME, NOS2, FLT3, STAT3, CXCR4, MMP9, PLSCR1, IL6, IL18RAP, SOCS1, DPYSL3, HCLS1, FAS, CCR7, JAK3

Monocyte chemotaxis

15

6.93E-04

CCL12, CALCA, ANXA1, CCL22, CCL20, CX3CL1, LGALS3, CCL9, CCL7, CCL6, CCL4, CCL3, CCL2, CCL19, FOLR2

Acute inflammatory response

12

0.0020

IL6, VCAM1, B4GALT1, IL1B, HP, DEFB1, CXCL1, TACR1, TNF, S100A8, ADRA2A, PTGES

Negative regulation of inflammatory response

25

0.0029

TNFAIP6, MEFV, ETS1, C1QTNF3, SOCS3, ZFP36, NT5E, CNR2, PBK, ACP5, NLRP3, APOE, LGALS9, SLIT2, IER3, GHSR, PTGIS, ACOD1, TNFRSF1B, TNFRSF1A, SLPI, TYRO3, PTPN2, ADA, CD44

Regulation of inflammatory response

20

0.0032

LYN, ANXA1, IL1R1, NOD2, ESR1, AGT, PYCARD, IL1RL2, SBNO2, CASP12, FABP4, BCL6, DUOXA1, CASP4, ZYX, NLRP3, JAK2, GGT1, MGLL, MYD88

Cell chemotaxis

20

0.0032

CXCL6, CXCL9, CCL22, VCAM1, C5AR2, C5AR1, PRKCD, ARHGEF16, ITGA1, HMGB2, CXCL1, AGTR1A, CXCL12, CCL6, GPR183, CCL4, C3AR1, ENPP2, ENG, HBEGF

Positive regulation of leukocyte migration

11

0.0065

SELP, TNFSF18, KITLG, CCL12, ITGB3, ITGA2, CCL2, TACR1, MMP9, SELE, TP53

Lymphocyte chemotaxis

11

0.0065

CCL9, CCL12, CCL22, CCL7, CCL20, CCL6, CCL4, CCL3, CCL2, CCL19, CX3CL1

Leukocyte chemotaxis

9

0.0078

CCR1, CNR2, GPR183, CCL4, CXCR5, S1PR1, CCL3, S100A9, CXCL2

Positive regulation of phagocytosis

16

0.0088

FCER1G, SLC11A1, PROS1, CYBA, NOD2, TNF, MYH9L1, PYCARD, C3, FCGR2A, IL1B, PTX3, CD36, FCGR1A, MFGE8, FCGR2B

Positive regulation of interleukin-6 production

17

0.0090

FCER1G, CYBA, NOD2, TICAM1, TNF, HSPD1, PYCARD, IL1RL2, IL6, IL1B, TNFSF9, CD36, ARHGEF2, LBP, RAB7B, IL6R, MYD88

Receptor-mediated endocytosis

25

0.022

IFITM3, LOXL4, CXCL16, LOXL2, VTN, ENDOU, ENPP2, OLR1, APOE, ENPP3, CD14, FCGR1A, LDLR, SBSPON, MSR1, CD163, SCARA5, CD300A, PRG4, SSC5D, TMPRSS13, ADRB3, TFR2, ACKR2, FCGR2B

Positive regulation of macrophage chemotaxis

8

0.027

TNFSF18, TRPV4, C5AR1, C3AR1, CCL2, THBS1, CX3CL1, CMKLR1

Positive regulation of phagocytosis, engulfment

7

0.036

ITGA2, F2RL1, PPARG, ANO6, CD36, LBP, FCGR1A

Response to interleukin-1

14

0.038

PCSK1, IL1RN, ANXA1, IL1R1, SPHK1, MMP3, CYBA, HNMT, ETS1, SELE, IRAK2, CHI3L1, LGALS9, MYD88

Positive regulation of leukocyte chemotaxis

8

0.039

CXCL10, F7, CXCL6, CXCL11, CXCL9, EDN3, CXCR2, F2RL1