Table 2 Alteration of biological functions related to metabolism in MACO model

Response to lipopolysaccharide

104

9.23E-24

CD86, IL1RN, NCF2, PROS1, SERPINE1, HP, TNF, ICAM1, NPPB, EDNRA, LGALS9, GGT1, IL6R, SLC11A1, DIO2, ACOD1, TICAM1, MAPKAPK3, SLPI, TRIB1, S100A9, S100A8, ABCG2, PTGES, PTGFR, MAOB, CNP, C5AR1, MGST2, CSF2RB, TNFRSF11B, MEFV, CYP27B1, SOCS3, SOCS1, THPO, CD14, NGFR, JUN, VCAM1, ACE, TNFRSF10B, IGF1, SERPINA3N, NFKB2, SELP, CXCL10, CXCL11, IL6, TG, GJB6, TRPV4, CD27, MYD88, PCSK1, CXCL6, CD40, CXCL9, SERPINA1, HMGB2, CXCL1, ADM, CXCL3, LITAF, THBD, CASP8, CASP3, ACP5, CCR7, LBP, JAK2, TIMP4, ABCC3, PTGIR, MMP3, PAWR, PLA2G4A, TNFRSF1B, NGF, MMP9, F3, TNFRSF1A, IL1B, TNFRSF26, CEBPB, PTGER2, PTGER3, NOD2, PTGS2, LTC4S, HSPD1, MUC2, CNR2, NOCT, CCL2, RELT, NOS2, GCH1, NOS3, ERBIN, FMO1, FAS, LTBR

Cellular response to lipopolysaccharide

53

1.21E-08

CD86, CXCL6, CSF3, CD40, SERPINE1, HMGB2, CXCL3, TNF, LITAF, CXCL2, CXCL16, ICAM1, PYCARD, FCGR3A, ZFP36, PLAU, ZC3H12A, PDE4B, TSPO, CD36, HMGCS2, LBP, JAK2, MAP2K3, ACOD1, TICAM1, TNFRSF1B, MMP9, PLSCR1, IL1B, RARA, IRF8, CEBPB, PTGER3, LTC4S, HIF1A, SBNO2, ADAMTS13, THPO, P2RY2, NLRP3, CCL2, CD14, GBP2, NOS2, CCL20, FN1, CXCL10, IL6, TNIP2, LCN2, FCGR2B

Retinoic acid biosynthetic process

6

0.022

ALDH1A3, DHRS9, CRABP2, RDH10, RBP1, ALDH1A1

Retinol metabolic process

12

0.044

ALDH1A3, RBP4, AKR1B10, RDH10, RBP1, RDH7, ALDH1A1, CYP1B1, LRAT, PLB1, RPE65, AKR1B8