Table 1 Alteration of biological functions related to angiogenesis and hypoxia in MACO model

Positive regulation of angiogenesis

43

8.11E-09

ECM1, ITGB3, C5AR1, SERPINE1, ITGB2, HSPB1, ADM, FGF1, THBS1, ETS1, FGF2, HIF1A, CX3CL1, AQP1, C3, LGALS3, CYSLTR2, C6, CXCR2, ZC3H12A, C3AR1, HMOX1, CYP1B1, CD34, ANGPT2, PTGIS, ANXA3, NOS3, SPHK1, CYBB, CELA1, MMP9, F3, TNFRSF1A, RUNX1, EREG, LRG1, DDAH1, IL1B, ADM2, CHI3L1, RAPGEF3, ENG

Response to hypoxia

73

1.08E-08

SERPINA1, HP, ADM, PLAT, PLOD2, PYGM, ECE1, HIF3A, TRH, TNF, ETS1, CX3CL1, LOXL2, SLC6A4, ICAM1, NPPB, NPPC, EDNRA, ALKBH5, PLAU, MB, CASP3, LEPR, PTGIS, ITGA2, MMP3, PRKCD, NGB, DIO3, CYBA, MMP9, HSPG2, TNFRSF1A, F7, MMP14, MMP13, CLDN3, IL1B, ALDOC, ANGPTL4, CRYAB, ENG, SHC1, CXCR4, HIF1A, HSPD1, PDLIM1, SOCS3, LDHA, MUC1, HMOX1, CCL2, ABCB1A, CAMK2G, LDLR, TGFB2, VCAM1, ANGPT2, TGFB1, ACE, NOS2, NOS3, TGFB3, CFLAR, IGF1, MT3, EPOR, FOSL2, CXCL12, GPR182, TACC3, FAS, ADA

Angiogenesis

53

3.55E-07

CLIC4, ECM1, NRP2, PLXND1, SERPINE1, HIF3A, FGF1, RBPJ, FGF2, TMEM100, ESM1, CASP8, SOX17, PLAU, GJA5, ANPEP, ZC3H12A, LEPR, RSPO3, PROK2, CYP1B1, EPHB3, ANXA2, MYH9L1, EREG, MMP14, ANGPTL4, MFGE8, RAPGEF3, ENG, CCL12, SHC1, THY1, PTGS2, HIF1A, DLL4, SRPX2, S1PR1, HMOX1, FLNA, TBX1, JUN, ANGPT2, NOS3, WNT7B, MCAM, FN1, TBX4, ADM2, FGF18, TGFBI, PLCD1, FGFR1

Regulation of blood pressure

24

1.63E-05

CALCA, ACE, NOS2, GCH1, ATP1A2, CYBA, ECE1, TACR1, ATP1A1, PTGS2, TRHDE, AGT, AGTR1A, PTGS1, SULT1A1, EDNRA, TRPV4, NPY, SCNN1A, C3AR1, HMOX1, PPARG, CD34, MYH6

Blood vessel remodeling

19

1.34E-04

TBX1, TGFB2, NOS2, SEMA3C, NOS3, ELN, CHD7, LIF, BGN, IGF1, AHR, RBPJ, DLL4, CSRP3, CBS, FLNA, RSPO3, BAK1, TGM2

Vasodilation

11

0.019

CALCA, CASR, GCH1, ALB, ITGA1, BDKRB2, APOE, KNG2, AGT, KNG1, CFTR

Blood vessel morphogenesis

13

0.019

TBX1, ANGPT2, FLT4, ETV2, AHR, SHB, THBS1, HIF1A, AMOT, GJA1, COL4A1, CYP1B1, FGFR1

Cellular oxidant detoxification

19

0.041

GPX2, SRXN1, TXNRD1, HP, MGST2, GSTT1, LTC4S, PTGS2, PRDX6, PTGS1, GSTZ1, DUOX1, SESN2, PXDN, APOE, GSTM7, S100A9, DUOX2, S100A8

Positive regulation of reactive oxygen species metabolic process

13

0.010

CDKN1A, RIPK3, GADD45A, ACOD1, F2, THBS1, PLAU, DUOXA1, ZC3H12A, TSPO, CYP1B1, CD36, TP53