From: Structural design of tetravalent T-cell engaging bispecific antibodies: improve developability by engineering disulfide bonds
Antibody
h8B-BsAb-WT
h8B-BsAb-2Â A
h8B-BsAb-4
h8B-BsAb
Glypican-3 (nM)
1. 9 ± 0.1
2.4 ± 0.1
3.2 ± 0.3
2.2 ± 0.1
CD3 (nM)
48.4 ± 6.2
42.1 ± 3.6
52.9 ± 5.4
85.3 ± 7.0